The 2008 Sierra 3500HD Crew Cab 2WD is a 4-door, up to 6-passenger full size pickup, available in 8 trims, ranging from the Work Truck Long Box SRW to the SLT Long Box DRW.

Upon introduction, the Work Truck Long Box SRW is equipped with a standard 6.0-liter, V8, 353-horsepower engine. The SLT Long Box DRW is equipped with a standard 6.0-liter, V8, 312-horsepower engine. A 6-speed automatic transmission with overdrive is standard on both trims.

The 2008 Sierra 3500HD Crew Cab 2WD is a carryover from 2007.