The 2008 Sierra 2500HD Crew Cab 4WD is a 4-door, up to 6-passenger full size pickup, available in 8 trims, ranging from the Work Truck Standard Box to the SLT Long Box.

Upon introduction, both trims are equipped with a standard 6.0-liter, V8, 353-horsepower engine. A 6-speed automatic transmission with overdrive is standard.

The 2008 Sierra 2500HD Crew Cab 4WD is a carryover from 2007.